Northeast India Research Articles

Treatment regimens and survival among patients with head and neck squamous cell carcinoma from Mizo tribal population in northeast India – a single centre, retrospective cohort study

Patients with early-stage head and neck squamous cell carcinoma (HNSCC) are treated using a single-modality approach that involves either surgery (S) or radiotherapy (RT). Conversely, those with advanced-stage disease are treated using a multi-modality approach incorporating a combination of chemotherapy (CT), RT and S. In addition to behavioural factors, such as alcohol and tobacco use, clinical parameters, such as leukocyte and neutrophil counts and T and N classification, have been linked to the survival of patients with head and neck cancer. This retrospective study was designed to provide insights into the types of treatment (induction chemotherapy [IC], concurrent chemoradiotherapy [CCRT], S and RT) administered to patients with HNSCC in Mizoram, analyse their 2-year outcome, and identify potential factors that may affect the response to treatment. A retrospective cohort study was conducted using patients diagnosed with HNSCC between 2017 and 2020 in Mizoram, northeast India. Data on clinical and demographic factors and treatments provided were collected from medical records from the Mizoram State Cancer Institute, Mizoram. Overall survival (OS) and progression free survival (PFS) were determined for each factor using the Kaplan-Meier method and compared using the log-rank test. Cox regression analysis was used to identify the factors that affected OS and PFS. Multicollinearity test was performed between the predictors using a variance inflation factor cut-off point of2. A retrospective study was performed on 210 patients with HNSCC who were followed up for a period of 2 years. The findings revealed that hypopharynx was the most affected site, followed by the nasopharynx, oral cavity, oropharynx, and larynx. Regarding treatment regimens, 85/210 (40.5%) of the patients received IC along with CCRT or RT in a sequential manner. Moreover, 86/210 (41.0%) underwent CCRT alone, 22/210 (10.5%) received RT alone and 17/210 (8.1%) underwent surgery followed by adjuvant CCRT or RT. Two-year OS and PFS estimated using the Kaplan-Meier analysis were 78.1% (95% CI=72.4%-84.2%) and 57.4% (95% CI=50.8%-64.8%), respectively. Log-rank test showed that leucocytosis (p=0.015) and neutrophilia (p=0.014) exerted effects on OS, whereas nodal involvement (p=0.005), neutrophilia (p=0.043) and IC (p=0.010) exerted effects on PFS. Multivariate analysis indicated that leucocytosis (p=0.010 [OS], 0.025 [PFS]), neutrophilia (p=0.029, 0.033), cancer site (laryngeal) (p=0.009, 0.028) and nodal involvement (N2) (p=0.020, 0.001) were predictors of poor OS and PFS. OS was better than PFS in HNSCC patients from Mizo population. Multi-modality approach offered survival advantages over single-modality approach. Leucocytosis, neutrophilia, nodal involvement, and cancer sites were associated with poor OS and PFS. More comprehensive research with a larger sample size is needed to confirm the findings from this study. There is no funding for this study.

Flood hazard zonation using GIS-based multi-parametric Analytical Hierarchy Process

Flood is considered to be a serious environmental hazard, especially in the tropical countries owing to its devastating consequence on human life. Tripura, a small hilly state of northeast India has faced large scale flood events over the last few decades. The present study is an attempt to identify flood hazard zones along the lower course of the Dhalai River flowing through the Dhalai District of Tripura State. An integrated approach of remote sensing and GIS coupled together with Analytical Hierarchy Process (AHP) was applied to identify the flood hazard zones of the study area and nine parameters were selected for this purpose. Thematic maps of the parameters were reclassified after assigning ranks to different classes. A pair-wise comparison matrix among all the parameters was prepared using AHP to determine the relative weight of each parameter. Finally, flood hazard zoning (FHZ) map of the study area was prepared by multiplying the reclassified values with the weighted values using raster calculator of Arc GIS 10.1. The outcome of the study revealed that 109.69 km2 (27.65%) of the study area fall under low flood risk category. At the same time, around 114.46 km2 (28.85%) and 90.43 km2 (22.80%) areas fall under moderate and high flood risk zone respectively. The study also disclosed that the high risk zone has maximum concentration of agricultural land (68.63%) and settled area (9.77%) in comparison to the other two zones which has increased vulnerability of flood hazard. The results validated the efficiency of AHP technique in generating fast and cost effective information regarding flood hazard assessment, especially in no data regions. Hence, the derived information could be very much helpful for the planners to prepare proper strategies to reduce the vulnerability of this hazard.

Modernity and Politics: A Study of Cultural Identity in Manipur

Cultural identity resonates with the categories of 'personal' and 'social' identity vis-à-vis the ideas of politics and culture. The emergence and evolution of the idea of social identity in any society's political, social, and cultural context are determined by imperialism. This imperialism may come in various forms in the vicinity, even overthrowing one language and culture over dominance. It is evident in the context of Indian history, partly and evidently. However, beyond the proximity of nationhood, few important insights, eras and events that took place in North-East India are so far neglected, especially in Manipur. Concerning this, we explored the role of imperialism in resolving a parcel of conflict on the cultural identity, language as one of the tools, and religion as the basis for cultural divides. In this review, we observed that language had shaped the foundation of historic and cultural identity in Manipur. Secondly, the tussle in religious practices, which, in turn, becomes a political tool for cultural identity and divides. Thirdly, the rise in the ethnic discontentment of various ethnicities and minorities settling in the State is due to the above two reasons.  

Exploration of the Molecular Mechanism Underlying the Antidiabetic Activity of a Northeast Indian Plant Zingiber rubens Roxb. through Modulation of PKC Phosphorylation

Background: Zingiber rubens Roxb., a new species of the Zingiberaceae family, is found profoundly in the Northeastern region of India. It is a rhizomatous geophyte and grows primarily in the seasonally dry tropical biome native to Indo-China regimens. Objective: The aim is to research the root part of this plant to discover active constituents and evaluate the molecular mechanism of antidiabetic activity Methods: The hydroalcoholic root extract of this plant (HAZR) was evaluated for in-vitro antioxidant assays α-amylase and α-glucosidase inhibition assay. Further, the antidiabetic activity assay was evaluated, exploring the molecular mechanism for modulating oxidative stress in tissue biochemical parameters and HbA1c. To explore the molecular mechanism, we also investigated the inhibition assay of protein kinase C (PKC) phosphorylation in mouse peritoneal macrophages. Results: The experiments' results helped to conclude that HAZR has potent antioxidant and antidiabetic activity and could have been embedded with potent active molecules. They also revealed the mechanism of action as inhibition of PKC phosphorylation, meriting further studies. Conclusion: The present study revealed that HAZR demonstrated its antidiabetic activity against diabetic animal models through oxidative stress-mediated PKC and TGF-β regulation in diabetic individuals.

Comprehensive landslide prediction mapping using bivariate statistical models of Mizoram state of Northeast India

ABSTRACT Landslides in the state of Mizoram result in damage to life and properties annually. The study focuses on landslide susceptibility zones by frequency ratio (FR), evidential belief function (EBF) and index of entropy (IOE) models. A total of 1,486 landslide points were used to build a relationship between 16 factors and landslide occurrences. The results reveal 14.44%, 19.64% and 3.55% of the area as very high susceptible zones in FR, EBF and IOE models, respectively. The AUC results support the adoption of the EBF model in land use planning and decision-making processes to enhance natural resource management and mitigate landslide risks in Mizoram.

Orographic effects on droughts in a monsoon climate with the world's highest rainfall

AbstractDrought, a recurring natural phenomenon in South Asia's monsoon climate, presents challenges in delineating its spatiotemporal patterns within complex topographies. This study investigated the impact of the orographic barrier in the rice‐dominated agricultural region of northeastern India and Bangladesh on drought characteristics during 1951–2020, employing the relative Standardized Precipitation Index (rSPI) and relative Standardized Precipitation‐Evapotranspiration Index (rSPEI) across 3‐, 6‐ and 12‐month scales. The results indicate that even in the rainiest region of the world, droughts extend beyond the limits of the dry season inherent in the monsoon regime. These mostly regional droughts exhibit weak correlations with the core of the Indian subcontinent and other parts of Bangladesh. The region's orographic barrier has a greater influence on drought intensity than on frequency. The rSPI index, which depends solely on rainfall, may overestimate drought intensity and frequency in regions with high seasonal/annual rainfall and substantial intermonthly variability. In contrast, the rSPEI index, which depends on both rainfall and potential evapotranspiration (PET), better reflects the spatial variation of drought in complex terrain, identifying the leeward hinterland of the orographic barrier as the most drought‐prone area. The two indices give similar results for drought characteristics away from the barrier. Furthermore, the orographic barrier exerts a negligible influence on the trends in rSPI and rSPEI. Principal component analysis (PCA) highlights the influences of the rainfall coefficient of variation and elevation on rSPI, while the PET coefficient of variation strongly influences rSPEI. Strategies to minimize the adverse effects of drought in complex topography and year‐round cropping should be local and season‐specific. These include using shorter‐growing, drought‐resistant rice varieties and adjusting planting schedules in rain shadow areas during the summer monsoon. These efforts should be complemented by integrating indigenous irrigation methods with modern practices such as roof water harvesting and tube wells in winter.

Low-cost Conventional PCR Techniques Enable Simultaneous Detection of Bacterial Sexually Transmitted Infections with Enhanced Sensitivity and Specificity

Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT) and Mycoplasma hominis (MH), the three most common treatable bacterial sexually transmitted infections (STIs) worldwide can lead to many complications if remain untreated. Screening of high-risk population with highly sensitive methods will lead to significant improvement in patient outcomes and will prevent downward transmission. The advantages of Polymerase chain reaction (PCR) based assay are not only high sensitivity and specificity, but also detection of multiple organisms in a single reaction which reduce the result turn-around time. The aim of the present study was to evaluate the feasibility of a multiplex PCR assay method targeting 16S rRNA gene for simultaneous detection of NG, CT and MH infection along with their trend and occurrence among high-risk population in Assam, Northeast India. A cross-sectional study was undertaken, where a total of 200 randomly selected patients from high-risk population were included. After validation of singleplex PCR, Multiplex PCR (M-PCR) was performed along with the traditional culture method for NG. The overall agreement of M-PCR with singleplex PCR was very high (100%). The occurrence of STI was found to be very high (101/200; 50.5%). Furthermore, co-infection was detected in 10/200; 5%) individuals. Infection was more common among young individuals (p<0.05) and males out-numbered females (p<0.05). The most common organism detected was CT (42/200; 21%) followed by NG (41/200; 20.5%) and MH (20/200; 10%). The M-PCR assay workflow is simple, cost effective and can be used in routine diagnostic laboratories with basic molecular facilities.

Seasonal diversity and abundance distribution of butterflies in Dihing Patkai national park, North East India

Seasonal diversity and abundance distribution of butterflies in Dihing Patkai national park, North East India

Antimicrobial and Probiotic Potential of Lactobacilli Associated with Traditional Fermented Beverages.

Fermented foods have been recognized as a source of probiotic bacteria which can have a positive effect when administered to humans and animals. Discovering new probiotics in fermented food products poses a global economic and health importance. In this study, we investigated the antimicrobial and probiotic potential of lactobacilli isolated from fermented beverages produced traditionally by ethnic groups in Northeast India. Out of thirty Lactobacilli, fifteen exhibited strong antimicrobial activity against Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter aerogenes with significant anti-biofilm and anti-quorum sensing activity. These isolates also showed characteristics associated with probiotic properties, such as tolerance to low pH and bile salts, survival in the gastric tract, auto-aggregation, and hydrophobicity without exhibiting hemolysis formation or resistance to certain antibiotics. The isolates were identified using gram staining, biochemical tests, and 16S rDNA sequencing. They exhibited probiotic potential, broad-spectrum of antibacterial activity, promising anti-biofilm, anti-quorum sensing activity, non-hemolytic, and tolerance to acidic pH and bile salts. Overall, four specific Lactobacillus isolates, Lactiplantibacillus plantarum BRD3A and Lacticaseibacillus paracasei RB10OW from fermented rice-based beverage, and Lactiplantibacillus plantarum RB30Y and Lacticaseibacillus paracasei MP11A from traditional local curd demonstrated potent antimicrobial and probiotic properties. These findings suggest that these lactobacilli isolates from fermented beverages have the potential to be used as probiotics with therapeutic benefits, highlighting the importance of traditional fermented foods for promoting gut health and infectious disease management.

Harnessing the Potential of Naturally-stabilized Earthen Ponds for Hill Aquaculture: A Demonstration Using Fish Species Combinations in Meghalaya

Aquaculture plays a pivotal role in sustaining livelihoods in the hilly regions of India. However, these areas face challenges in aquaculture production due to prolonged cold climates and suboptimal water temperatures. This study aimed to develop a low-input aquaculture system tailored for hilly conditions in Meghalaya, Northeast India, by employing naturally-stabilized earthen ponds. Ranging in area from 700 to 1500 m2 and with a depth of 1.5 to 2m, these ponds were stocked with fish of different feeding niches at a density of 5000 fish per hectare, with the following compositions: 20% Catla, 40% Rohu, and 40% Gonia in Pond 1; 20% Catla, 40% Rohu, and 40% Common carp in Pond 2; and 20% Catla, 40% Rohu, 20% Gonia, and 20% Common carp in Pond 3. The average size was 28.4±1.8 g for Catla, 7.5±0.4 g for Rohu, 7.6±0.5 g for Gonia, and 10.8±1.3 g for Common carp. The culture duration spanned 8 months, with the initial two months involving feeding fish with commercial feed and the subsequent 6 months with farm-made feed at 2% body weight. Monthly assessments of water quality parameters and bi-monthly evaluations of fish growth attributes were conducted. Analysis of water temperature revealed suboptimal average temperatures ranging from 19.5°C to 20.2°C. Fish production attributes at the end of 8-month was found to be better in Pond 2 (survival 83.2%; biomass 1227.5 kg/ha; FCR 1.53), followed by Pond 3 (survival 82.3%; biomass 1114.8 kg/ha; FCR 1.60) and Pond 1 (survival 81.1%; biomass 998.7 kg/ha; FCR 1.64). Ponds containing Common carp exhibited lower biomass, potentially due to their aggressive feeding behavior leading to competition with co-habiting fishes. It is concluded that naturally-stabilized earthen ponds in hilly areas could serve as a valuable resource for hill aquaculture. However, optimizing productivity requires appropriate fish combinations to minimize inter-specific competitions.

Hydropower Politics in Northeast India: Dam Development Contestations, Electoral Politics and Power Reconfigurations in Sikkim

Around the world, the development of large dams has been increasingly contested. India is no exception and has seen the mobilisation of powerful domestic and transnational socio-environmental movements against dams over more than four decades. In this context, the State of Sikkim in northeast India has been entangled in prolonged hydropower development conflicts since the late 1990s. This article analyses these conflictive entanglements between the Government of India, the State Government of Sikkim, power companies and Sikkim’s autochthonous tribe, the Lepchas. It zooms in on the period of 2011–2017, which saw an abrupt escalation of the conflicts to analyse the messy, deeply political and often unpredictable and contradictory world of dam construction and its contestations. Our analysis is informed by the power cube framework developed by John Gaventa. Our analysis shows how hydropower development is deeply intertwined with local patronage relationships. We show how local elections bring out dam conflict and the operation of power into the open, sometimes leading to abrupt and unexpected switches in positions in relation to hydropower development. We show that these switches should be seen not only as “strategic electoral tactics” but also and importantly as contentious political struggles that (re)configure power in the region. We show how in this process, powerful political actors continuously seek to stabilise power relations among the governing and the governed, choreographing a specific socio-hydraulic order that stretches way beyond simple pro- and anti-dam actors and coalitions as it is embedded in deep hydro(-electro) politics and power plays.

QUESTIONS OF KNOWLEDGE AND POWER: CONTESTATIONS WITH SPECIAL REFERENCE TO THE PERFORMANCE OF DOUDINIS OF THE BODOS OF ASSAM

This research paper attempts to explore the notions of knowledge and power in the traditions of doudini (priestess) of the Bodo tribe of Assam, North-East India. The present paper tries to argue that although a doudini possesses traditional knowledge and supernatural power, she is deprived of the rights to equality and freedom. The doudini through her ritualistic dance performance plays the role of a mediator between the people and the Gods. The raw blood of the sacrificial animals is consumed by her in the Kherai festival, an important ritual of the Bathou religion. She is then charmed by the chants of the priest and falls into a trance and transforms into a spiritual being. The community addresses her as nasoni (dancer) and some as doudini(spirit), depending on the status attributed to her in the particular society. The doudini plays many parts which are presented in a series to the same audience. Though the ritual is performed both by female priest and male priest, their role differs as doudini has to accomplish more performances compared to male priest. The doudini does not have freedom to act on her own as she performs, based on the rules set by the system. The doudini does not enjoy freedom throughout the entire process of the ritual as she is bound to perform every act set by the system.The present study has made a critical analysis on the role of doudini, discriminated on the ground of gender and questions her status based on the social system.

Patterns of failure in patients with nasopharyngeal cancer of Northeastern region of India: a retrospective observational study.

We aimed to analyzepatterns of failure and disease volume-treatment outcomes in patients with Nasopharyngeal carcinoma (NPC) treated with definitive radiation with or without concurrent chemotherapy at a tertiary cancer centre in northeast India. From February 2018 to February 2022, 99 histopathologically proved non-metastatic NPC patients treated with curative-intent RT with or without chemotherapy were retrospectively analyzed. Locally advanced patients received neoadjuvant or adjuvant chemotherapy. The Cox proportional hazards model was used to investigate the impact of various prognostic factors on locoregional free survival (LRFS), distant metastasis free survival (DMFS), progression free survival (PFS) and overall survival (OS). The log-rank test and Kaplan-Meir curves compared outcome variables based on ROC analysis-classified tumor volume. During a median follow up of 25.4months (17.3-39.2), 35(35.4%) patients developed recurrence. Twenty-three patients developed locoregional failures, of which 11 were in-field; 12 patient showed an out-field failure. The 3-year LRFS, DMFS, PFS and OS was 71.10%, 70.90%, 64.10% and 74.10% respectively. There was statistically significant difference in LRFS according to T staging (p < 0.0001). Gross tumor volume (GTVp) and gross nodal volume (GTVn) were an independent prognostic factor for OS, PFS, LRFS and DMFS. The cut-off volumes for GTVp and GTVn for distant metastases and locoregional failure, respectively, were found to be 13 and 22.7mL and 3.7 and 39.2mL, respectively, by ROC curve analysis. Based on this, 99 patients were divided into three subgroups. OS demonstrated significant differences among patients in different volume subgroups for GTVp (p = 0.03) and GTVn (p = 0.00024). For NPC patients who undergo curative IMRT, primary tumour and nodal volumes are independent prognostic indicators. GTVp and GTVn are highly predictive of local control, distant metastases, disease-free survival, and overall survival. This justifies their use as quantitative prognostic indicator for NPC.

Prevalence of Anemia in Pregnant Women and Its Associated Socioeconomic Factors

Background: Anemia during pregnancy is an important public health problem, in developing countries. This community based study was conducted in Northeast India to study the prevalence of anemia along with the associated socioeconomic factors.&#x0D; Methods: The present one-year cross sectional study was carried out in the selected villages under Lahowal Block of Dibrugarh District and the relevant data was collected in a pre-designed and pre-tested proforma by house to house interviews. The sample size was calculated 310. Clinical examination was done and haemoglobin estimation was performed using Sahli’s acid hematin method. Data were analyzed in Microsoft Excel using percentage, range, t-test and ANOVA; wherever applicable. A significance level of 5% was taken with 95% confidence interval&#x0D; Results: Anemia was seen in 89.68% of the subjects. The highest mean hemoglobin (Hb) level was observed in the 1st trimester subjects (9.14 gm/dl), while the lowest mean Hb-level was observed in the 3rd trimester subjects (8.90 gm/dl). A significant difference was observed between the mean Hb-levels of the study subjects belonging to nuclear families and joint families, subjects belonging to different socio-economic status, different levels of education, different professions, those consuming tobacco and those not consuming tobacco, and those consuming betel nut and not consuming betel nut.&#x0D; Conclusion: There was a high prevalence of anemia in pregnancy which was related to the socioeconomic status, occupational status, level of education, type of family, and personal habits in these women.

An integrative taxonomic revision of the Trimeresurus popeiorum group of pitvipers (Reptilia: Serpentes: Viperidae) with descriptions of two new species from the Indo-Burma Biodiversity Hotspot

Abstract Despite recent progress in our understanding of diversity within the genus Trimeresurus Lacépède, 1804, the subgenus Popeia Malhotra &amp; Thorpe, 2004, distributed across most parts of East and Southeast Asia, remains taxonomically challenging. We applied an integrative taxonomic approach including analyses of morphological data and four mitochondrial genes (12S and 16S rRNA, cytochrome b, and NADH dehydrogenase subunit 4), along with examination of available type material, to address longstanding taxonomic questions in one clade within Popeia, the T. popeiorum group, and reveal a high level of hidden diversity of these snakes in the Indo-Burma Biodiversity Hotspot. We confirm that T. popeiorum Smith, 1937 sensu stricto is restricted to Northeast India, eastern Nepal, southern Bhutan, southeastern Bangladesh, western Yunnan Province (China), and northern and southwestern Myanmar. We further confirm that the recently described species T. yingjiangensis Chen et al., 2019 is a junior synonym of T. popeiorum. In addition, we discovered that the combination Trimesurus [sic] elegans Gray, 1853 is a valid senior synonym of T. popeiorum and threatens the stability of the latter taxon. Therefore, in order to protect the nomen popeiorum and in accordance with Article 23.9 of the International Code of Zoological Nomenclature, we regard the taxon Trimesurus elegans as a nomen oblitum and render Trimeresurus popeiorum a nomen protectum. Examination of a larger series of specimens allows us to describe two new cryptic species of Trimeresurus from the Indo-Burma Region. This study brings the total number of species in the subgenus Popeia to six and also suggests that the subspecific taxonomy of the T. sabahi complex requires further investigation. We urge adequate actions regarding the conservation of the newly discovered species and recommend further studies on their toxicology.

Preliminary selection of wild male kiwifruit (Actinidia callosa var. strigillosa C. F. Liang) accessions in North Sikkim, India, for future breeding programmes

ABSTRACT The flower morphology and phenology of 10 healthy, profusely flowering wild male kiwifruit (Actinidia callosa var. strigillosa C. F. Liang) accessions growing in North Sikkim district in Sikkim state, Northeast India, were analysed in 2021–2022. There was distinct variation among the accessions in the number of flowers per inflorescence, number of sepals and petals, colour of the sepals, arrangement of the petals, and average number of stamens, as well as the timing and duration of flowering. Accessions SKNFF-04 and SKNLC-21 were superior in terms of pollinating traits, with the highest average numbers of flowers and stamens per vine and the longest duration of flowering. Principal component analysis (PCA) revealed that the first and second principal components (PC1 and PC2) had eigenvalues greater than 1 and together explained 95.13% of the variation. Hierarchical cluster analysis categorised the accessions into two major clusters: Cluster I with eight accessions and Cluster II with the two superior accessions. The presence of the pleiochasium inflorescence type among all the observed accessions is of particular significance, as it can increase the efficacy of male selection in kiwifruit breeding programmes. This research sets the stage for further investigations into the potential advantages and unique characteristics of wild kiwifruit germplasm.

Asian Blepharoplasty with Concurrent Ptosis Correction by Lps Plication: Our Experiences in Northeast India

Background: Asian blepharoplasty is one of the most performed facial cosmetic procedures in northeastern India. Undiagnosed ptosis often goes unnoticed in many Asian blepharoplasty patients. To achieve proper symmetry, its essential to address ptosis simuntaneously during Asian blepharoplasty.  In this study, the author discuss ten cases of Asian blepharoplasty in which simultaneous ptosis correction was performed by lps plication.

Systematic Review and Geospatial Modeling of Molecular Markers of Resistance to Artemisinins and Sulfadoxine-Pyrimethamine in Plasmodium falciparum in India.

Surveillance for genetic markers of resistance can provide valuable information on the likely efficacy of antimalarials but needs to be targeted to ensure optimal use of resources. We conducted a systematic search and review of publications in seven databases to compile resistance marker data from studies in India. The sample collection from the studies identified from this search was conducted between 1994 and 2020, and these studies were published between 1994 and 2022. In all, Plasmodium falciparum Kelch13 (PfK13), P. falciparum dihydropteroate synthase, and P. falciparum dihydrofolate reductase (PfDHPS) genotype data from 2,953, 4,148, and 4,222 blood samples from patients with laboratory-confirmed malaria, respectively, were extracted from these publications and uploaded onto the WorldWide Antimalarial Resistance Network molecular surveyors. These data were fed into hierarchical geostatistical models to produce maps with a predicted prevalence of the PfK13 and PfDHPS markers, and of the associated uncertainty. Zones with a predicted PfDHPS 540E prevalence of >15% were identified in central, eastern, and northeastern India. The predicted prevalence of PfK13 mutants was nonzero at only a few locations, but were within or adjacent to the zones with >15% prevalence of PfDHPS 540E. There may be a greater probability of artesunate-sulfadoxine-pyrimethamine failures in these regions, but these predictions need confirmation. This work can be applied in India and elsewhere to help identify the treatments most likely to be effective for malaria elimination.

‘You are not Sikkimese enough’: Understanding collective action tendencies of old settlers in Sikkim using SIMCA

AbstractThe current study analyses the motivators and inhibitors of collective action tendency using the Social Identity Model of Collective Action (SIMCA). The study was conducted with a minority and state‐based repressed group known as the old settlers in Sikkim, India. The old settlers are a community that have been historically settled in Sikkim prior to the state's merger with India in 1975. They are racially and ethnically different from the majority population of northeasterners in Sikkim and face both institutional and interpersonal discrimination. A qualitative approach using semi‐structured interviews with 11 old settlers was taken to delineate SIMCA variables – moral conviction, identity, injustice and efficacy – within the context of northeast India. Collective action was motivated through moral conviction via principles of equality and unequal treatment and outsider status, identity via politicisation of identity, creation of social movement organisations, injustice via anger and fraternal resentment and efficacy via marches and legal recourses. Collective action was inhibited through moral conviction via denial of violation, identity via acculturation, injustice via fear and efficacy via learned helplessness. These findings indicate that in state‐based repressed groups, collective action tendencies must be understood from a context‐specific lens that attempts to understand both motivating and inhibitory factors.

Ensembling machine learning models to identify forest fire-susceptible zones in Northeast India

Forest fires pose significant challenges by disrupting ecological balance, impacting socio-economic harmony, and raising global concerns. North-East India (NEI) experiences high incidences of forest fires, making it crucial to implement suitable management measures considering the driving forces influencing fire likelihood. This study aims to identify forest fire susceptibility zones in NEI by using five machine-learning modeling approaches, Boosted Regression Tree (BRT), Random Forest (RF), Support Vector Machine (SVM), Classification and Regression Tree (CART), and Multivariate Adaptive Regression Splines (MARS), and an ensemble method. Forest fire data from the SNPP – VIIRS sensor (2018–2019) were rectified for spatial autocorrelation. Thirty-two responsive predictor variables related to topographic, climatic, biophysical, and anthropogenic factors were used as model inputs and multicollinearity analysis was performed to eliminate highly correlated predictors. Results indicate that the southern and southeastern regions of NEI, characterized by ample solar radiation, enhanced vegetation index, high human population density, and jhum cultivation, contribute significantly to higher susceptibility to forest fires. The Random Forest model performs best among the models employed, achieving an AUC value of 0.87. The ensemble susceptibility map, binarized based on AUC weighting, covers 29.54% of the total geographic area and 44.42% of the forested area of NEI. The vulnerability levels vary among states, with Mizoram showing the highest susceptibility at 89.27% and Sikkim exhibiting the lowest vulnerability at only 0.49% of their respective geographic areas. This map provides valuable insights for implementing effective forest fire management plans in the region. Moreover, the methodology utilized in this study, which incorporates satellite imagery, GIS techniques, and improved modeling techniques, can be replicated in any geographical region worldwide to facilitate effective forest fire management at a regional to large scale.